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Proof-of-concept studies were performed using humanized H3L3 CLDN1 mAbs in cell line-derived (CDX) and patient-derived xenograft (PDX) mouse models

Chronic liver fibrosis develops into liver cirrhosis, and up to 30% of liver cirrhosis cases eventually progress into hepatocellular carcinoma (Zhang et al., 2019)

Furthermore, data governance should be aligned with international standards, such as the General Data Protection Regulation (GDPR) in Europe and similar regulations in other regions, to ensure the ethical and legal handling of metabolomics data